Protocol Comparison
Side-by-side comparison of HBOT protocols across UHMS-approved and emerging indications and longevity applications. Cmd-P / Ctrl-P prints cleanly to PDF.
Indications: UHMS-approved and emerging (24)
| Indication | Pressure | Duration | Sessions | Frequency | Level | Basis |
|---|---|---|---|---|---|---|
| Air or Gas Embolism Acute Ischemias | 2.8 – 3.0 ATA | 90 min | 1 – 3 (emergency) | Continuous until stable | A | UHMS / Emergency Standard |
| Carbon Monoxide Poisoning Toxicities | 2.4 – 2.8 ATA | 90 min | 1 – 3 (emergency) | Continuous until resolved | A | UHMS / Emergency Standard |
| Clostridial Myositis & Myonecrosis (Gas Gangrene) Infectious Diseases | 2.0 – 2.5 ATA | 90 min | 20 – 30 | Once daily, 5×/week | A | UHMS / Standard of Care |
| Crush Injury & Compartment Syndrome Acute Ischemias | 2.0 – 2.4 ATA | 90 min | 30 – 40 | Once daily, 5×/week | A | UHMS / FDA-Approved |
| Decompression Sickness Gas/Bubble Disorders | 2.0 – 2.5 ATA | 90 min | 20 – 30 | Once daily, 5×/week | A | UHMS / Standard of Care |
| Enhancement of Healing in Selected Problem Wounds Wound Healing | 2.0 – 2.4 ATA | 90 min | 20 – 30 | Once daily, 5×/week | A | UHMS / Standard of Care |
| Exceptional Blood Loss Anemia Haematological Disorders | 2.0 – 2.5 ATA | 90 min | 20 – 40 | Once daily, 5×/week | B | UHMS / Standard of Care |
| Intracranial Abscess Infectious Diseases | 2.0 – 2.5 ATA | 90 min | 30 – 60 | Once daily, 5×/week | B | UHMS / Standard of Care |
| Necrotizing Soft Tissue Infections Infectious Diseases | 2.0 – 2.5 ATA | 90 min | 20 – 30 | Once daily, 5×/week | A | UHMS / Standard of Care |
| Refractory Osteomyelitis Infectious Diseases | 2.0 – 2.4 ATA | 90 min | 30 – 60 | Once daily, 5×/week | A | UHMS / Standard of Care |
| Delayed Radiation Injury (Soft Tissue & Bony Necrosis) Wound Healing | 2.0 – 2.4 ATA | 90 min | 30 – 60 | Once daily, 5×/week | A | UHMS / Standard of Care |
| Compromised Skin Grafts & Flaps Acute Ischemias | 2.0 – 2.4 ATA | 90 min | 20 – 30 | Once daily, 5×/week | B | UHMS / Standard of Care |
| Idiopathic Sudden Sensorineural Hearing Loss Sensory Disorders | 2.0 – 2.5 ATA | 90 min | 10 – 20 | Once daily, 5×/week | B | UHMS / Standard of Care |
| Central Retinal Artery Occlusion Sensory Disorders | 2.0 – 2.8 ATA | 90 min | 1 – 3 (emergency) | Immediately, then daily | B | UHMS / Emergency Standard |
| Long COVID Post-Viral Syndromes · Emerging Evidence | 2.0 ATA | 90 min | 40 | 5×/week | B | Zilberman-Itskovich et al., 2022 (RCT) |
| Fibromyalgia Chronic Pain Syndromes · Emerging Evidence | 2.0 ATA | 90 min | 40 | 5×/week | B | Efrati et al., 2015 (prospective controlled trial) |
| Inflammatory Dermatoses Inflammatory Skin Disease · Emerging Evidence | 2.0 – 2.8 ATA | 60 – 90 min | 6 – 30 (highly variable) | Daily, protocol-dependent | C | Case Reports & Small Studies (not standardised) |
| Aesthetic & Reconstructive Recovery Aesthetic & Reconstructive Surgery · Emerging Evidence | 2.0 – 2.5 ATA | 60 – 90 min | 5 – 10 (aesthetic) / 20 – 30 (graft/flap salvage) | Once daily; within 24 h of surgery for salvage cases | B | Case–Control Study (Neel et al., 2023) + Reviews |
| Endometriosis Reproductive Health · Emerging Evidence | Not standardised | Not standardised | Not standardised (HEROES trial protocol pending publication) | Not standardised | C | Translational (animal models) + Registered Trial Awaiting Results |
| Post-Traumatic Stress Disorder (PTSD) Neuropsychiatric · Emerging Evidence | 2 ATA | 90 min | 60 | Daily, with air breaks | B | Doenyas-Barak et al., 2024 (RCT) |
| Chronic Post-Stroke Recovery Acquired Brain Injury · Emerging Evidence | 2 ATA | 90 min | 40 | Once daily, 5×/week | B | Efrati et al., 2013 (RCT) |
| Traumatic Brain Injury & Post-Concussion Syndrome Acquired Brain Injury · Emerging Evidence | 1.5 ATA | 60 min | 40 – 60 | Once daily, 5×/week | B | Boussi-Gross et al., 2013; Hadanny et al., 2022 (RCTs) |
| Acute Thermal Burns Wound Healing | Not standardised | Not standardised | Not standardised | Not standardised | B | Protocols vary between burn centres |
| Avascular Necrosis of the Femoral Head Bone Disorders | 2.5 ATA | 90 min | 60 (2 × 30) | Daily; 30-day break between cycles | B | Bosco et al., 2018 |
Longevity applications (6)
| Application | Pressure | Duration | Sessions | Frequency | Basis |
|---|---|---|---|---|---|
| Telomere Lengthening | 2.0 ATA | 90 min | 60 | Once daily, 5×/week | Hadanny et al., 2020 (RCT) |
| Senescent Cell Clearance | 2.0 ATA | 90 min | 60 | Once daily, 5×/week | Hadanny et al., 2020 (RCT) |
| Cognitive Enhancement | 2.0 ATA | 90 min | 60 | Once daily, 5×/week | Hadanny et al., 2020 (RCT) |
| Stem Cell Mobilization | 2.0 – 2.4 ATA | 90 min | 20 – 40 | Once daily, 5×/week | Thom et al., 2006 / Clinical Research |
| Athletic Performance & Recovery | 1.5 – 2.4 ATA | 60 – 90 min | 10 – 20 per cycle | Post-exercise or daily | Systematic Review & Meta-Analysis |
| Collagen Production & Skin Health | 2 ATA | 90 min | 60 | Daily, 5×/week, with air breaks | Hachmo et al., 2021 (prospective trial) |
All protocols are sourced from peer-reviewed publications cited on each indication's detail page. Evidence levels follow UHMS grading criteria. To export this matrix as PDF, use your browser's print function (Cmd-P / Ctrl-P).