Longevity application
Senescent Cell Clearance
Senescent "zombie" cells accumulate with age and drive inflammation. In the same healthy-older-adult research, hyperbaric oxygen reduced the number of senescent immune (T) cells — the first senolytic effect shown from a non-pharmacological intervention. The result is promising but early, and not an established anti-ageing treatment.
37%
Reduction in senescent T-cells
Mechanism
HBOT induces selective apoptosis of senescent cells through ROS-mediated signaling pathways. Senescent cells accumulate with age and drive the 'inflammaging' phenotype associated with age-related diseases.
Treatment protocol
Protocol
Pressure
2.0 ATA
Duration
90 min
Sessions
60
Frequency
Once daily, 5×/week
Evidence basis: Hadanny et al., 2020 (RCT)
Key References:
See full citations on the references page.
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